Fifty years after "Phantom Blood," Jonathan Joestar's grandson Joseph Joestar investigates rumors about Speedwagon's death, ultimately becoming entangled with the revival of the Pillar Men, ancient humanoids of impossible power who are tied to the creation of the Stone Mask. Joseph ultimately teams up with Caesar Zeppeli, Will's grandson, and Caesar's teacher Lisa Lisa, who is linked to Joseph. They try to stop the Pillar Men led by Kars and AC/DC from obtaining a mystical artifact in Lisa Lisa's possession that will grant them complete immortality and bring about the end of the world.

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