The story involves Arbuckle coming to the western town of Mad Dog Gulch after being thrown off a train and chased by Indians. He teams up with gambler/saloon owner Bill Bullhum, in trying to keep the evil Wild Bill Hickup away from Salvation Army girl, Salvation Sue. Fatty and Buster have a series of adventures trying to beat St. John, until they discover his one weakness: his ticklishness.

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