Manay Po tells the story of Luz, a small time jeweler who dreams of making it big so as to provide a better life for her family. Her life revolves around her brood of three, namely, Oscar, Orson and Orwell and her live-in boyfriend Gerry. With the help of her good friend and maid Maritess, Luz was able to raise her children normally despite the absence of a husband. In spite of her children's questionable sexualities, their family paints a picture of a happy family - a home filled with laughter and unconditional love.

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