After the death in suspicious circumstances of Charles Baskerville, the last descendant of the lineage of the Baskervilles, Henry, returned to the old family mansion. The charismatic detective Sherlock Holmes and his faithful assistant, Dr. Watson, investigating the case, and discover the existence of a supernatural hound that in addition murderer according to history, killed many years ago Hugo Baskerville, the first of the line, and it seems that the curse stalks his descendants.

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